National participating agencies have signed a CAN Participation Agreement that covers the national parent organization and all subsidiary units.

• ACTS World Relief*
• American Red Cross
• Boat People SOS
• Catholic Charities USA
• Christian Reformed World Relief Committee
• City Team Ministries
• Church World Service, Inc
• Eagles Wings Foundation
• Episcopal Relief and Development
• Evangelical Free Church of America Crisis Response
• FEMA*
• Forward Edge International
• Habitat for Humanity
• Hands on USA
• Hope Coalition America
• International Relief and Development
• ICNA Relief USA
• Lutheran Disaster Response
• Mennonite Disaster Services
• National Alliance of Vietnamese American Service Agencies
• National Center for Missing and Exploited Children
• National VOAD
• National Council on Aging
• National Disability Rights Network
• National Spinal Cord Injury Foundation
• New Beginnings National Disaster Relief
• North American Mission Board
• Operation Blessing
• Presbyterian Disaster Assistance
• Samaritan's Purse
• Southern Baptist Convention
• Society of Saint Vincent De Paul
• The Salvation Army USA
• Tzu Chi Foundation
• United Church of Christ
• United Methodist Committee on Relief
• United Way Worldwide
• Volunteers of America
• World Foundation for Children*